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    题名: Transcriptional and subcellular regulation of the TRIP-Br family
    作者: ;2.Lai, IL;Wang, SY;姚雅莉;Yao, Ya-Li;Yang, WM
    贡献者: 生物科技學系
    关键词: Bromodomain;PCAF;STAF65γ;KAP1
    日期: 2007-02
    上传时间: 2012-11-23 17:10:31 (UTC+8)
    摘要: TRIP-Brs are a recently discovered set of proteins whose functions remain poorly characterized. Here we report the identification of TRIP-Br3 as a member of the TRIP-Br family along with evidence showing that TRIP-Brs interact with bromodomain-containing transcriptional cofactors PCAF, STAF65γ, and KAP1. PCAF, a histone acetyltransferase; STAF65γ, a protein associated with histone acetylation activity; and KAP1, a corepressor, influence the transcriptional activity of TRIP-Brs differentially. Finally, while all three TRIP-Brs are localized to the nucleus, TRIP-Br2 and TRIP-Br3 are also present in the cytoplasm through interaction with CRM1. Our results suggest that different TRIP-Brs function by interacting with a wide variety of bromodomain-containing transcriptional regulators in different subcellular locales.
    關聯: GENE,388(1-2),102–109.
    显示于类别:[生物科技學系] 期刊論文


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