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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16286


    Title: Short-Term versus Long-Term Intermittent Hypobaric Hypoxia on Cardiac fibrosis and Fas-Death-Receptor Dependent Apoptotic Pathway in Rat Hearts
    Authors: ;Lin, Yueh-Min;Huang, Shu-Kuei;Wang, Hsueh Fang;Chen, Li-Mien;Tsai, Fuu-Jen;Hsu, Hsi-Hsien;Kuo, Chia-Hua;Shyi-Gang, P.Wang;黃志揚;HUANG, CHIH-YANG;Lee, Shin-Da
    Contributors: 生物科技學系
    Keywords: cardiac fibrosis;cell apoptosis;high altitude;Fas pathway;time course
    Date: 2008-10
    Issue Date: 2012-11-23 17:10:58 (UTC+8)
    Abstract: "It is unknown if short-term and long-term intermittent hypobaric hypoxic challenges both exert
    pro-apoptotic effects on Fas death receptor-dependent apoptotic pathway in rat hearts. Seventy-two
    Sprague-Dawley rats were randomly assigned into two groups. First, short-term intermittent hypobaric
    hypoxia (STIHH)-normobaric normoxia (n = 12), hypobaric hypoxia (380 mmHg, 12% O2
    , 8 hrs/day) for
    1 day (n = 12), and for 4 days (n = 12) and second, long-term intermittent hypobaric hypoxia (LTIHH)-
    normobaric normoxia (n = 12), hypobaric hypoxia for 1 week (n = 12) and 2 weeks (n = 12). After STIHH
    or LTIHH challenge, Fas receptor related pathway and histopathological analysis in the excised left
    ventricle was determined by Western blotting, RT-PCR, Hematoxylin-eosin staining, Masson trichrome
    staining and TUNEL assay. Fas death receptor and TNFα were significantly decreased after STIHH
    whereas Fas receptor, TNFα, FAS-associated death domain (FADD), and caspase 8 were increased after
    LTIHH. In addition, cardiomyocyte disarray and fibrosis were observed in 1 week LTIHH. Cardiac
    hypertrophy and more severe disarray, fibrosis and cardiac apoptotic activities were observed in 2 week
    LTIHH. STIHH exerts anti-apoptotic effects on hearts such as downregulation of TNFα and Fas
    receptor whereas LTIHH exerts pro-apoptotic effects such as upregulation of TNFα and Fas-mediated
    apoptotic pathways and lead to cardiac fibrosis and apoptosis. Our findings imply that short-term
    versus long-term intermittent hypobaric hypoxia exerted protective versus deleterious effects on hearts."
    Relation: CHINESE JOURNAL OF PHYSIOLOGY
    Appears in Collections:[生物科技學系] 期刊論文

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