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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16302


    Title: RhoGDIβ-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK
    Authors: 黃志揚;HUANG, CHIH-YANG;Yang, Li-Chiu;Liu, Kuan-Yu;Liao, Pao-Hsin;Chou, Janet Ing-Yuh;Chou, Ming-Yung;Lin, Wei-Wen;Yang, Jaw-Ji
    Contributors: 生物科技學系
    Date: 2009-01
    Issue Date: 2012-11-23 17:11:11 (UTC+8)
    Abstract: We found that overexpression of RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and suppressed cell cycle progression in a cultured cardiomyoblast cell line. Knockdown of RhoGDIβ expression by RNA interference blocked hypertrophic growth. We further demonstrated that RhoGDIβ physically interacts with ZAK and is phosphorylated by ZAK in vitro, and this phosphorylation negatively regulates RhoGDIβ functions. Moreover, the ZAK-RhoGDIβ interaction may maintain ZAK in an inactive hypophosphorylated form. These two proteins could negatively regulate one another such that ZAK suppresses RhoGDIβ functions through phosphorylation and RhoGDIβ counteracts the effects of ZAK by physical interaction. Knockdown of ZAK expression in ZAK- and RhoGDIβ-expressing cells by ZAK-specific RNA interference restored the full functions of RhoGDIβ.
    Relation: JOURNAL OF BIOMEDICAL SCIENCE
    Appears in Collections:[生物科技學系] 期刊論文

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