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http://asiair.asia.edu.tw/ir/handle/310904400/16309
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| Title: | Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease. |
| Authors: | ;Chen, SY;萬磊;Wan, Lei;Huang, YC;Sheu, JJ;Lan, YC;Lai, CH;Lin, CW;Chang, JS;Tsai, Y;Liu, SP;Lin, YJ;Tsai, FJ |
| Contributors: | 生物科技學系 |
| Keywords: | Kawasaki disease (KD);interleukin 18 (IL-18);polymorphism |
| Date: | 2009-02 |
| Issue Date: | 2012-11-23 17:11:17 (UTC+8) |
| Abstract: | "Interleukin-18 (IL-18)-656T/G, -607A/C,
and -137C/G promoter polymorphisms
had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C
polymorphism at coding position 105
(rs549908) has been linked with asthma,
rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-
18 105A/C genetic polymorphism confers
KD susceptibility. Study participants were
Taiwanese KD patients and a healthy
control group. Our data indicated that the
frequency of C allele was significantly
higher in the patient group (13.9%) than in
the control group (2.7%; Po0.0001, odds
ratio [OR] 5 5.93; 95% confidence interval
[CI]5 2.57–13.73). Therefore, persons with
the C allele may have higher risk of deve
loping KD. In addition, compared with the
haplotype frequencies between case and
control groups, the KD patients with TACC
haplotype appeared to be a significant
‘‘at-risk’’ haplotype compared with other
haplotypes (OR: 4.62, 95% CI: 1.71–12.43;
P 50.001). KD patient with the TAGA
haplotype appeared to be a significant
‘‘protective’’ haplotype compared with
other haplotypes (OR: 0.51, 95%
CI:0.29–0.89; P5 0.017). Our results suggest that 105A/C polymorphism and the
haplotypes in IL-18 gene are associated with
the risk of KD in Taiwanese population.
Clin. Lab. Anal. 23:71–76, 2009. r 2009
Wiley-Liss, Inc." |
| Relation: | JOURNAL OF CLINICAL LABORATORY ANALYSIS |
| Appears in Collections: | [生物科技學系] 期刊論文
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