ASIA unversity:Item 310904400/16309
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    题名: Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.
    作者: ;Chen, SY;萬磊;Wan, Lei;Huang, YC;Sheu, JJ;Lan, YC;Lai, CH;Lin, CW;Chang, JS;Tsai, Y;Liu, SP;Lin, YJ;Tsai, FJ
    贡献者: 生物科技學系
    关键词: Kawasaki disease (KD);interleukin 18 (IL-18);polymorphism
    日期: 2009-02
    上传时间: 2012-11-23 17:11:17 (UTC+8)
    摘要: "Interleukin-18 (IL-18)-656T/G, -607A/C,
    and -137C/G promoter polymorphisms
    had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C
    polymorphism at coding position 105
    (rs549908) has been linked with asthma,
    rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-
    18 105A/C genetic polymorphism confers
    KD susceptibility. Study participants were
    Taiwanese KD patients and a healthy
    control group. Our data indicated that the
    frequency of C allele was significantly
    higher in the patient group (13.9%) than in
    the control group (2.7%; Po0.0001, odds
    ratio [OR] 5 5.93; 95% confidence interval
    [CI]5 2.57–13.73). Therefore, persons with
    the C allele may have higher risk of deve
    loping KD. In addition, compared with the
    haplotype frequencies between case and
    control groups, the KD patients with TACC
    haplotype appeared to be a significant
    ‘‘at-risk’’ haplotype compared with other
    haplotypes (OR: 4.62, 95% CI: 1.71–12.43;
    P 50.001). KD patient with the TAGA
    haplotype appeared to be a significant
    ‘‘protective’’ haplotype compared with
    other haplotypes (OR: 0.51, 95%
    CI:0.29–0.89; P5 0.017). Our results suggest that 105A/C polymorphism and the
    haplotypes in IL-18 gene are associated with
    the risk of KD in Taiwanese population.
    Clin. Lab. Anal. 23:71–76, 2009. r 2009
    Wiley-Liss, Inc."
    關聯: JOURNAL OF CLINICAL LABORATORY ANALYSIS
    显示于类别:[生物科技學系] 期刊論文

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