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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16331

    Title: ZAK negatively regulates RhoGDIβ-induced Rac1-mediated hypertrophic growth and cell migration
    Authors: 黃志揚;HUANG, CHIH-YANG;Yang, Li-Chiu;Liu, Kuan-Yu;Chang, I-Chang;Liao, Pao-Hsin;Chou, Janet Ing-Yuh;Chou, Ming-Yung;Lin, Wei-Wen;Yang, Jaw-Ji
    Contributors: 生物科技學系
    Date: 2009-06
    Issue Date: 2012-11-23 17:11:36 (UTC+8)
    Abstract: RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDIβ plays a previously undefined role in regulating Rac1 expression through transcription to induce hypertrophic growth and cell migration and that these functions are blocked by the expression of a dominant-negative form of Rac1. We also demonstrated that knockdown of RhoGDIβ expression by RNA interference blocked RhoGDIβ-induced Rac1 expression and cell migration. We demonstrated that the co-expression of ZAK and RhoGDIβ in cells resulted in an inhibition in the activity of ZAK to induce ANF expression. Knockdown of ZAK expression in ZAK-RhoGDIβ-expressing cells by ZAK-specific RNA interference restored the activities of RhoGDIβ.
    Appears in Collections:[生物科技學系] 期刊論文

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