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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16334


    Title: Effects of b-carotene on antioxidant status in rats with chronic alcohol consumption
    Authors: ;Lin, Wan-Teng;Huang, Chi-Chang;Lin, Tien-Jen;Chen, Jiun-Rong;Shieh, Ming-Jer;Peng, Hsiang-Chi;Yang, Suh-Ching;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Date: 2009-07
    Issue Date: 2012-11-23 17:11:38 (UTC+8)
    Abstract: This study examined the effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption. At the beginning of experiment (week 0), according to both the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, rats (n = 24) were divided into 3 groups and fed with a standard diet (group C), a diet containing ethanol (group E), or a diet containing ethanol and beta-carotene (group E+B). After 10 weeks, plasma AST and ALT, fat accumulation in the liver, antioxidant enzyme activities in erythrocytes and the liver, malondialdehyde (MDA), and alpha-tocopherol and retinol in plasma and hepatic samples were analyzed. The chronic alcohol diet significantly increased AST and ALT levels in plasma, and these changes were prevented by supplementing the diet with beta-carotene. Glutathione (GSH) in erythrocytes and in the liver was significantly elevated in rats fed with a diet containing beta-carotene. The results indicate that beta-carotene supplementation can prevent ethanol-induced liver damage and increase GSH concentrations in erythrocytes and the liver.
    (c) 2009 John Wiley & Sons, Ltd.
    Relation: CELL BIOCHEMISTRY AND FUNCTION;27(6):344-50.
    Appears in Collections:[生物科技學系] 期刊論文

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