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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16365


    Title: Drug Design for the Influenza A Virus Subtype H1N1
    Authors: 蔡輔仁;Tsai, Fuu-Jen;蔡長海;陳語謙;Chen, Calvin Yu-chian
    Contributors: 生物科技學系
    Keywords: H1N1;Influenza;Oseltamivir;Neuraminidase;Haemagglutinin;Dual target;Swine flu
    Date: 2009-10
    Issue Date: 2012-11-23 17:12:04 (UTC+8)
    Abstract: An outbreak of influenza A virus subtype H1N1, also known as swine flu, in Mexico was occurred in April
    2009. To design drugs for treating this epidemic is urgency. In this study, we employed the new
    sequences (2009) to build the N1 simulation structure by homology modeling, which has been checked
    for high reliability by Verify Score and Ramachandran plot. The latest H1 homology model was employed
    from Chen’s report. 365,602 compounds from NCI database have been screened by docking study of H1
    and N1, respectively. And then, nine candidates were screened and suggested as potent dual target
    candidates from the docking studies. In our investigation, drug resistance was found by our molecular
    simulation in the new N1 modeling structure to oseltamivir. However, the mechanism is still not clear;
    further clinical investigations are urgently required.
    Relation: IEEE/ACM Transactions on Computational Biology and Bioinformatics
    Appears in Collections:[生物科技學系] 期刊論文

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