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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16372


    Title: Reducing without Side Effects? A Novel Strategy for Designing the PPAR Agonists
    Authors: 蔡輔仁;Tsai, Fuu-Jen;蔡長海;陳語謙;Chen, Calvin Yu-chian
    Contributors: 生物科技學系
    Keywords: PPAR;3D-QSAR;Dual agonists;CoMFA;CMSIA
    Date: 2009-10
    Issue Date: 2012-11-23 17:12:11 (UTC+8)
    Abstract: "Abstract—In this investigation, the CoMFA and CoMSIA in the
    three-dimensional quantitative structure-activity relationship (3DQSAR) studies were implemented to search for the pharmacophore
    features in each target receptor. QSAR pharmacophores hypothesis
    models were made from a series of ligands by their activity values.
    Besides, we made use of the docking strategy between the structures
    of each PPARs subtype. Eventually, selectivity factor is employed
    for us to search new drugs. By means of taking advantage of the
    results of 3D-QSAR studies and docking strategy, we search out the
    specific drugs fitting the two PPAR subtypes but repelling the other
    PPAR subtype effectively and selectively. "
    Relation: IEEE/ACM Transactions on Computational Biology and Bioinformatics
    Appears in Collections:[生物科技學系] 期刊論文

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