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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16391


    Title: Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model
    Authors: ;Su, Chin-Cheng;楊家欣;Yang, Jai-Sing;呂啟誠;Lu, Chi-Cheng;江若華;Chiang, Jo-Hua;吳長霖;Wu, Chang-Lin;Lin, Jen-Jyh;賴光啟;Lai, Kuang-Chi;夏德椿;Hsia, Te-Chun;呂旭峰;Lu, Hsu-Feng;范宗宸;Fan, Ming-Jen;鍾景光;Chung, Jing-gung
    Contributors: 生物科技學系
    Date: 2010-01
    Issue Date: 2012-11-23 17:12:27 (UTC+8)
    Abstract: Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
    Relation: PHYTOTHERAPY RESEARCH;Volume(24):189–192
    Appears in Collections:[生物科技學系] 期刊論文

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