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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16426

    Title: Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells
    Authors: 許成光;Hsu, Cheng-Kuang;王建國;Wang, Chien-Kuo;張清堯;Chang, Ching-Yao
    Contributors: 生物科技學系
    Keywords: Helicobacter pylori;Solanum lyratum;human gastric epithelial cells, apoptosis.
    Date: 2010-04
    Issue Date: 2012-11-23 17:12:55 (UTC+8)
    Abstract: "Helicobacter pylori infection is associated with
    chronic gastritis, peptic ulcers, and gastric cancer. The
    effects of Solanum lyratum extract (SLE) on anti-H. pylori
    activity and H. pylori-induced apoptosis were investigated.
    SLE showed a moderate ability in inhibiting growth of H.
    pylori and also in interrupting the association of bacteria
    with host cells. SLE was also able to suppress H. pyloriinduced apoptosis. SLE inhibited caspase-8 activation,
    thereby preventing the release of cytochrome c from
    mitochondria and activation of the subsequent downstream
    apoptotic pathway. Thus, SLE may offer a new approach for
    the treatment of H. pylori by down-regulation of apoptosis in
    the H. pylori infected gastric epithelium. As it does not
    directly target bacteria, SLE treatment might not cause
    development of resistant strains. "
    Appears in Collections:[生物科技學系] 期刊論文

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