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    題名: Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells
    作者: 許成光;Hsu, Cheng-Kuang;王建國;Wang, Chien-Kuo;張清堯;Chang, Ching-Yao
    貢獻者: 生物科技學系
    關鍵詞: Helicobacter pylori;Solanum lyratum;human gastric epithelial cells, apoptosis.
    日期: 2010-04
    上傳時間: 2012-11-23 17:12:55 (UTC+8)
    摘要: "Helicobacter pylori infection is associated with
    chronic gastritis, peptic ulcers, and gastric cancer. The
    effects of Solanum lyratum extract (SLE) on anti-H. pylori
    activity and H. pylori-induced apoptosis were investigated.
    SLE showed a moderate ability in inhibiting growth of H.
    pylori and also in interrupting the association of bacteria
    with host cells. SLE was also able to suppress H. pyloriinduced apoptosis. SLE inhibited caspase-8 activation,
    thereby preventing the release of cytochrome c from
    mitochondria and activation of the subsequent downstream
    apoptotic pathway. Thus, SLE may offer a new approach for
    the treatment of H. pylori by down-regulation of apoptosis in
    the H. pylori infected gastric epithelium. As it does not
    directly target bacteria, SLE treatment might not cause
    development of resistant strains. "
    顯示於類別:[生物科技學系] 期刊論文


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