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    题名: Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma
    作者: 林振文;Lin, Cheng-Wen;黃素華;Huang, Su-Hua
    贡献者: 生物科技學系
    关键词: Oral squamous cell carcinoma;Biomarkers;Haptoglobin;Proteomic analysis
    日期: 2010-05
    上传时间: 2012-11-23 17:13:01 (UTC+8)
    Identification of tumor biomarkers to assist early diagnosis and monitoring of disease progression may potentially decrease the mortality and morbidity associated with oral cancer.
    A mouse model with oral squamous cell carcinoma (OSCC) induced by 4-nitroquinoline 1-oxide (4-NQO)/arecoline in drinking water was established to discover stage-associated biomarkers. A proteomics approach, immunoblot and immunohistochemical analysis were used to validate the expressed biomarkers in mice with OSCC. Human plasma samples were also collected and candidate biomarkers were evaluated using enzyme-linked immunosorbent assay.
    Proteomic profiling of mouse plasma samples indicated that haptoglobin and apolipoprotein A1 precursor were up-regulated in the mice with OSCC. Immunoblotting of plasma samples and immunohistochemical analysis of oral tissues showed a significantly higher level of haptoglobin in the OSCC mice than in the control mice. The expression of haptoglobin in human plasma samples from 52 patients with OSCC indicated a strong correlation between the increasing levels of haptoglobin and the clinical stages of OSCC (P<0.01).
    These results suggest that haptoglobin has a great potential as a sensitive plasma biomarker for early detection of patients with OSCC.
    Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.
    關聯: Elsevier Oceanography Series;411(13-14):984-91.
    显示于类别:[生物科技學系] 期刊論文


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