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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16434


    Title: Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response
    Authors: 游春淑;Yu, Chun-Shu;賴光啟;Lai, Kuang-Chi;楊家欣;Yang, Jai-Sing;江若華;Chiang, Jo-Hua;呂啟誠;Lu, Chi-Cheng;吳長霖;Wu, Chang-Lin;林景彬;Lin, Jing-Pin;廖慶隆;Liao, Ching-Lung;唐娜櫻;Tang, Nou-Ying;Wood, W.Gibson;鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: quercetin;WEHI-3 cells;BALB/c mice;in vivo;phagocytosis
    quercetin;WEHI-3 cells;BALB/c mice;in vivo;phagocytosis
    Date: 2010-05
    Issue Date: 2012-11-23 17:13:02 (UTC+8)
    Abstract: Enhanced flavonoid consumption is closely related with a reduced cancer incidence as shown in epidemiological studies. Quercetin (3,5,7,3',4'-pentahydroxylflavone) is one of the active components of flavonoids which exist in natural plants, particularly in onions and fruits. It was reported that quercetin induced apoptosis in human cancer cell lines, including human leukemia HL-60 cells, but there is no available information as to its effects on leukemia cells in vivo. The purpose of the present studies was to focus on the in vivo effects of quercetin on leukemia WEHI-3 cells. The effects of quercetin on WEHI-3 cells injected into BALB/c mice were examined. Quercetin decreased the percentage of Mac-3 and CD11b markers, suggesting that the differentiation of the precursors of macrophages and T cells was inhibited. There was no effect on CD3 levels but increased CD19 levels. Quercetin decreased the weight of the spleen and liver compared with the olive oil treated animals. Quercetin stimulated macrophage phagocytosis of cells isolated from peritoneum. Quercetin also promoted natural killer cell activity. Based on pathological examination, an effect of quercetin was observed in the spleen of mice previously injected with WEHI-3 cells. Apparently, quercetin affects WEHI-3 cells in vivo.
    Relation: PHYTOTHERAPY RESEARCH, 24(2):163-8
    Appears in Collections:[生物科技學系] 期刊論文

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