English  |  正體中文  |  简体中文  |  Items with full text/Total items : 92472/107769 (86%)
Visitors : 19091040      Online Users : 411
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16443

    Title: Downregulation of microRNA miR-520h by E1A Contributes to Anti-cancer Activity
    Authors: 蘇振良;Su, Jen-Liang;陳柏森;Poshen, B.Chen;陳雅惠;Chen, Ya-Huey;陳尚志;Chen, Shang-Chih;張薏雯;Chang, Yi-Wen;冉毅華;Jan, Yi-Hua;程曉韻;Cheng, Xiaoyun;蕭宏昇;Hsiao, Michael;洪明奇;Hung, Mien-Chie
    Contributors: 生物科技學系
    Date: 2010-06
    Issue Date: 2012-11-23 17:13:10 (UTC+8)
    Abstract: The leading cause of death in cancer patients is cancer metastasis, for which there is no effective treatment. MicroRNAs (miRNA) have been shown to play a significant role in cancer metastasis through regulation of gene expression. The adenovirus type 5 E1A (E1A) is associated with multiple tumor-suppressing activities including the inhibition of metastasis, and E1A gene therapies have been tested in several clinical trials. However, the mechanisms involved in E1A-mediated tumor-suppressing activities are not yet completely defined. Here, we showed that E1A downregulated the expression of the miRNA miR-520h, which was critical for E1A-mediated cancer cell mobility and in vitro invasion activity. In addition, we identified a signal cascade, namely, E1A-->miRNA-520h-->PP2A/C-->IkappaB kinase-->NF-kappaB-->Twist, in which E1A inhibited the expression of Twist through downregulation of miR-520h and the signal cascade. Our results indicated a functional link between miR-520h and tumorigenicity/invasive ability and provided a new insight into the role of E1A-mediated miRNA regulation in tumor suppression. Therefore, the results identified a new cascade of E1A-mediated tumor suppression activity via downregulation of miRNA-520h expression.
    Relation: CANCER RESEARCH; 70(12):5096-108.
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback