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    题名: Downregulation of microRNA miR-520h by E1A Contributes to Anti-cancer Activity
    作者: 蘇振良;Su, Jen-Liang;陳柏森;Poshen, B.Chen;陳雅惠;Chen, Ya-Huey;陳尚志;Chen, Shang-Chih;張薏雯;Chang, Yi-Wen;冉毅華;Jan, Yi-Hua;程曉韻;Cheng, Xiaoyun;蕭宏昇;Hsiao, Michael;洪明奇;Hung, Mien-Chie
    贡献者: 生物科技學系
    日期: 2010-06
    上传时间: 2012-11-23 17:13:10 (UTC+8)
    摘要: The leading cause of death in cancer patients is cancer metastasis, for which there is no effective treatment. MicroRNAs (miRNA) have been shown to play a significant role in cancer metastasis through regulation of gene expression. The adenovirus type 5 E1A (E1A) is associated with multiple tumor-suppressing activities including the inhibition of metastasis, and E1A gene therapies have been tested in several clinical trials. However, the mechanisms involved in E1A-mediated tumor-suppressing activities are not yet completely defined. Here, we showed that E1A downregulated the expression of the miRNA miR-520h, which was critical for E1A-mediated cancer cell mobility and in vitro invasion activity. In addition, we identified a signal cascade, namely, E1A-->miRNA-520h-->PP2A/C-->IkappaB kinase-->NF-kappaB-->Twist, in which E1A inhibited the expression of Twist through downregulation of miR-520h and the signal cascade. Our results indicated a functional link between miR-520h and tumorigenicity/invasive ability and provided a new insight into the role of E1A-mediated miRNA regulation in tumor suppression. Therefore, the results identified a new cascade of E1A-mediated tumor suppression activity via downregulation of miRNA-520h expression.
    關聯: CANCER RESEARCH; 70(12):5096-108.
    显示于类别:[生物科技學系] 期刊論文


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