ASIA unversity:Item 310904400/16458
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90074/105197 (86%)
Visitors : 7169257      Online Users : 44
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16458


    Title: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells
    Authors: 呂啟誠;Lu, Chi-Cheng;楊家欣;Yang, Jai-Sing;黃安正;Huang, An-Cheng;夏德椿;Hsia, Te-Chun;周淑姿;Chou, Su-Tze;郭昭麟;Kuo, Chao-Lin;呂旭峰;Lu, Hsu-Feng;李宗翰;Lee, Tsung-Han;Wellington, G.Wood;鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: "Adenosine triphosphate;Chrysophanol;J5 human liver cancer cells;Necrosis;Reactive oxygen species;"
    Date: 2010-07
    Issue Date: 2012-11-23 17:13:22 (UTC+8)
    Abstract: "Anthraquinone compounds have been shown to induce apoptosis in different cancer cell
    types. Effects of chrysophanol, an anthraquinone compound, on cancer cell death have not
    been well studied. The goal of this study was to examine if chrysophanol had cytotoxic effects
    and if such effects involved apoptosis or necrosis in J5 human liver cancer cells. Chrysophanol induced necrosis in J5 cells in a dose- and time-dependent manner. Non-apoptotic cell
    death was induced by chrysophanol in J5 cells and was characterized by caspase independence, delayed externalization of phosphatidylserine and plasma membrane disruption.
    Blockage of apoptotic induction by a general caspase inhibitor (z-VAD-fmk) failed to protect
    cells against chrysophanol-induced cell death. The levels of reactive oxygen species production and loss of mitochondrial membrane potential (DCm) were also determined to assess the
    effects of chrysophanol. However, reductions in adenosine triphosphate levels and increases
    in lactate dehydrogenase activity indicated that chrysophanol stimulated necrotic cell death.
    In summary, human liver cancer cells treated with chrysophanol exhibited a cellular pattern
    associated with necrosis and not apoptosis."
    Relation: MOLECULAR NUTRITION & FOOD RESEARCH
    Appears in Collections:[Department of Biotechnology] Journal Article

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML132View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback