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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16463

    Title: Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.
    Authors: ;Wang, YN.;Yamaguchi, H;Hsu, JM;洪明奇;Hung, Mien-Chie
    Contributors: 生物科技學系
    Keywords: EGFR family receptors;nuclear trafficking;integral membrane proteins
    Date: 2010-07
    Issue Date: 2012-11-23 17:13:26 (UTC+8)
    Abstract: Multiple membrane-bound receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR) and ErbB-2, have been reported to be localized in the nucleus, where emerging evidence suggests that they are involved in transcriptional regulation, cell proliferation, DNA repair and chemo- and radio-resistance. Recent studies have shown that endocytosis and endosomal sorting are involved in the nuclear transport of cell surface RTKs. However, the detailed mechanism by which the full-length receptors embedded in the endosomal membrane travel all the way from the cell surface to the early endosomes and pass through the nuclear pore complexes is unknown. This important area has been overlooked for decades, which has hindered progress in our understanding of nuclear RTKs' functions. Here, we discuss the putative mechanisms by which EGFR family RTKs are shuttled into the nucleus. Understanding the trafficking mechanisms as to how RTKs are transported from the cell surface to the nucleus will significantly contribute to understanding the functions of the nuclear RTKs.
    Relation: ONCOGENE
    Appears in Collections:[生物科技學系] 期刊論文

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