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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16471


    Title: Disease Association of the CD103 Polymorphisms in Taiwan Chinese Graves' Ophthalmopathy Patients
    Authors: ;Liu, Y.H.;Chen, R.H.;Chen, W.C.;Tsai, Y.;萬磊;Wan, Lei;Tsai, F.J.
    Contributors: 生物科技學系
    Date: 2010-08
    Issue Date: 2012-11-23 17:13:32 (UTC+8)
    Abstract: OBJECTIVE:
    To evaluate whether variations in the CD103 gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease.
    DESIGN:
    Case-control study.
    PARTICIPANTS:
    A total of 484 Chinese patients with Graves' disease in Taiwan, including 203 patients with GO and 281 patients without GO, were enrolled.
    METHODS:
    Five single nucleotide polymorphisms (SNPs) in CD103 were genotyped using an assay-on-demand allelic discrimination assay and detection system according to the manufacturer's instructions.
    MAIN OUTCOME MEASURES:
    Association of SNPs in CD103 with the development of GO.
    RESULTS:
    The CD103 SNP rs11652878 was associated with GO, which may decrease the risk of GO by 1.57-fold (P = 0.029). The Ht5-GCGCG haplotype, composed of 5 SNPs in the CD103 gene (rs1716, rs3744679, rs11652878, rs16953477, and rs9905739), were protective haplotypes (P = 0.010). Moreover, the heterozygous genotype (Ht5/non-Ht5) was correlated with a reduced risk of GO and high grades of goiter as compared with the non-Ht5/non-Ht5 genotype (P = 0.006 and P = 0.048, respectively). Logistic analysis confirmed the contribution of CD103 rs11652878 to the protection of GO.
    CONCLUSIONS:
    These data suggest that patients with Graves' disease in the presence of the G allele of SNP rs11652878, especially Ht5-GCGCG, in CD103 are less susceptible toward the development of GO.
    Copyright 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
    Relation: OPHTHALMOLOGY; 117(8):1645-51.
    Appears in Collections:[生物科技學系] 期刊論文

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