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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16477

    Title: Significant Association of XPD Asp312Asn Polymorphism with Breast Cancer in Taiwanese Patients
    Authors: ;Wang, Hwei-Chung;Liu, Chiu-Shong;Wang, Chung-Hsing;Tsai, Ru-Yin;Tsai, Chia-Wen;Wang, Rou-Fen;Chang, Chao-Hsiang;Chen, Yueh-Sheng;Chiu, Chang-Fang;Bau, Da-Tian;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: XPD;Asp312Asn;polymorphism;breast cancer Taiwanese
    Date: 2010-08
    Issue Date: 2012-11-23 17:13:37 (UTC+8)
    Abstract: "The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to
    play a major role in the development of human malignancy. Polymorphic variants of XPD, at Asp312Asn
    (rs1799793), Lys751Gln (rs13181), and promoter C-114G (rs3810366), were chosen to be studied of their
    association with breast cancer susceptibility in a central Taiwanese population. In this hospital-based
    case-control study, the associations of XPD Asp312Asn, Lys751Gln and promoter C-114G polymorphisms
    with breast cancer risk were investigated. In total, 1232 patients with breast cancer and 1433 healthy
    controls recruited from the China Medical Hospital in Central Taiwan were genotyped. We found a
    significant difference in the frequency of the XPD Asp312Asn genotype, but not the XPD Lys751Gln or
    promoter C-114G genotypes, between the breast cancer and control groups. Those who had G/A or
    A/A at XPD Asp312Asn showed a 1.78-fold (95% confidence interval = 1.53-2.08) increased risk of breast
    cancer compared to those with G/G. As for XPD Lys751Gln or promoter C-114G, there was no difference
    in distribution between the breast cancer and control groups. Our findings suggest that the heterozygous
    and homozygous A allele of the XPD Asp312Asn may be associated with the development of breast cancer
    and may be a useful marker for primary prevention and anticancer intervention."
    Appears in Collections:[生物科技學系] 期刊論文

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