ASIA unversity:Item 310904400/16498
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    题名: Activation of MDM2 by Akt in mammary epithelium accelerates mammary tumorigenesis.
    作者: ;Cheng, X;Xia, W;Yang, JY;Hsu, JL;Lang, J;Chou, CK;Sun, HL;Wyzomierski, SL;Mills, GB;Muller, WJ;Yu, D;洪明奇;Hung, Mien-Chie
    贡献者: 生物科技學系
    日期: 2010-10
    上传时间: 2012-11-23 17:13:53 (UTC+8)
    摘要: Amplification or overexpression of MDM2 promotes a variety of human tumors by degrading tumor suppressor proteins such as p53. Phosphorylation of MDM2 on serines 166 and 186 by the survival kinase Akt inhibits p53-mediated apoptosis. However, it is unclear whether this pathway contributes to normal or malignant pathophysiology in vivo. To address these questions, we generated transgenic mice expressing the Akt-phosphorylated form of MDM2 (MDM2DDS166D/S186D) in the mammary epithelium. Activation of MDM2 delayed mammary gland involution and accelerated tumor progression in MMTV/neu transgenic mice by inhibiting apoptosis in a manner associated with decreased p53 expression. Our findings offer in vivo evidence that activation of MDM2 by Akt contributes to mammary development and tumorigenesis.
    關聯: CANCER RESEARCH
    显示于类别:[生物科技學系] 期刊論文

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