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    题名: SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer
    作者: 鍾景光;Chung, Jing-Gung
    贡献者: 生物科技學系
    关键词: Type II sodium-dependent phosphate transporter;SLC34A2;diagnosis;therapy;breast cancer.
    日期: 2010-10
    上传时间: 2012-11-23 17:13:55 (UTC+8)
    摘要: "The purpose of this study was to estimate the role
    of the SLC34A2 gene in breast cancer. A total of 146 samples
    were collected from breast cancer tissues and their adjacent
    normal breast tissues. Reverse transcription and real-time
    polymerase chain reaction were used to estimate gene
    expression levels. There was a significantly increased gene
    expression of SLC34A2 (normal tissues: 6.71±0.77; tumour
    tissues: 10.29±0.80) among breast cancer tissues compared
    with normal tissues. However, there was no significant
    association between overall survival and the gene expression
    level of SLC34A2. Moreover, a significant overexpression of
    CA125 (normal tissues: 7.26±0.62; tumour tissues:
    10.51±0.58) in breast cancer tissues and a significant
    correlation between SLC34A2 and CA125 gene expressions
    were found. Our results suggested SLC34A2 to be involved
    in the development of breast cancer; this gene may therefore
    be a novel marker for the detection of breast cancer and act
    as a target gene in therapeutic strategies."
    显示于类别:[生物科技學系] 期刊論文


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