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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16511

    Title: The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo
    Authors: 鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: CHM-1;leukemia WEHI-3 cells;leukemia murine model;in vivo
    Date: 2010-11
    Issue Date: 2012-11-23 17:14:02 (UTC+8)
    Abstract: "CHM-1 [2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one] is a quinolone derivative that has been reported to induce apoptosis and inhibit invasion of cancer cells. However, there is no available information to address the effects of CHM-1 on leukemia cells in vivo. Therefore, the present study examined the effects of CHM-1 using a mouse model of leukemia. We established leukemia in mice by injecting WEHI-3 cells into BALB/c mice. Mice were then treated with or without CHM-1 (5 and 10 mg/kg). CHM-1 promoted the total survival rate of leukemic mice and these effects were dose-dependent. CHM-1 increased body weight and decreased spleen weight, but did not affect liver weight. The levels of cell markers Mac-3 and CD11b were reduced by CHM-1, indicating that the differentiation of macrophage precursor cells was inhibited. Levels of CD3 and CD19 were induced by CHM-1, suggesting that the differentiation of precursors of T and B cells was promoted in PBMC. Results of the present study indicate that CHM-1 has an inhibitory effect on leukemia induced in mice in vivo and warrants further study as to the mechanisms and effects in other types of cancer.[ABSTRACT FROM AUTHOR]

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    Appears in Collections:[生物科技學系] 期刊論文

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