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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16514


    Title: Alzheimer's Disease: Aging, Insomnia and Epigenetics
    Authors: ;Wu, Tzong-Yuan;陳持平;Chen, Chih-Ping;Jinn, Tzyy-Rong
    Contributors: 生物科技學系
    Keywords: Alzheimer’s disease, epigenetics, insomnia, orexin
    Date: 2010-12
    Issue Date: 2012-11-23 17:14:05 (UTC+8)
    Abstract: "Alzheimer’s disease (AD) is the most common form of dementia. Severe memory loss, confusion, and impaired
    cognitive abilities characterize AD. It was only a century after Alzheimer’s discovery that scientists were able to
    shed light on the mystery of its cause, but AD has also become a globally important health issue and the treatment of AD is a challenge for modern medicine. At present, there are five drugs approved in the United States
    for the treatment of AD, namely, donepezil, galantamine, rivastigmine, and tacrine (which are all cholinesterase
    inhibitors); and memantine (which is a glutamate receptor antagonist). However, these drugs show only modest
    effects on AD patients. Thus, new investigations are necessary for pharmacological development in AD. This brief
    review focuses on new studies that demonstrate the link between epigenetics and AD, and explores the possibility
    that insomnia may be one factor that effects AD. [Taiwan J Obstet Gynecol 2010;49(4):468–472]"
    Relation: Taiwanese Journal of Obstetrics & Gynecology
    Appears in Collections:[生物科技學系] 期刊論文

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