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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16559


    Title: Amino Acid Concentrations in Cerebrospinal Fluid in Children with Acute Lymphoblastic Leukemia undergoing Chemotherapy
    Authors: 蔡進發;Jeffrey, J.P.Tsai
    Contributors: 生物與醫學資訊學系
    Keywords: Acute lymphoblastic leukemia;Acute lymphocytic leukemia;ALL;CNS leukemia;CSF amino acids;CNS prophylaxis
    Date: 2005
    Issue Date: 2012-11-23 17:14:34 (UTC+8)
    Abstract: Cerebrospinal fluid (CSF) amino acid concentrations were measured in 45 children with acute lymphoblastic leukemia (ALL). Central nervous system (CNS) disease was absent in 34 and present in 11 (Groups L and M, respectively) at diagnosis. Thirty-two otherwise healthy children with febrile convulsions were studied for comparison. Results from this study show that glutamine levels at Day 0 were significantly higher in patients than in controls. Patients in Group M had elevated glutamine levels compared to Group L. In comparison, at Day 14, concentrations of glutamine and asparagine decreased, while glutamic acid amounts increased significantly in Group L. Glutamine levels fell at Day 42 in Group M, which may have resulted from more intensive treatment. From this study we hypothesise that higher baseline glutamine levels are indicative of a greater risk for CNS leukemia. Large-scale prospective trials are required to confirm increased baseline CSF glutamine levels in ALL patients, to identify glutamine as a marker for CNS disease and to clarify underlying mechanisms regulating glutamine in ALL.
    Relation: EUROPEAN JOURNAL OF CANCER
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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