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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16568

    Title: Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells
    Authors: 鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: "Safrole;oral cancer HSC-3 cells;apoptosis;caspase cascades;xenograft model "
    Date: 2011-02
    Issue Date: 2012-11-23 17:14:38 (UTC+8)
    Abstract: Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca2+ and a reduction in the mitochondrial membrane potential (ΔΨm). Changes in the membrane potential were associated with changes in the Bax, release of cytochrome c from mitochondria, and activation of downstream caspases-9 and -3, resulting in apoptotic cell death. In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. Western blotting and flow cytometric analysis studies confirmed that safrole-mediated apoptotic cell death of HSC-3 cells is regulated by cytosolic Ca2+ and by mitochondria- and Fas-dependent pathways
    Appears in Collections:[生物科技學系] 期刊論文

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