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    Title: Applications of domain-domain interactions in pathway study
    Authors: 吳家樂;Ng, Ka-Lok;劉湘川;Liu, Hsiang-Chuan
    Contributors: 生物與醫學資訊學系
    Keywords: Protein–protein interaction;Domain–domain interaction;Chemotaxis pathway;Blood coagulation pathway;MAPK pathway;Entropy
    Date: 2008
    Issue Date: 2012-11-23 17:14:53 (UTC+8)
    Abstract: The domain combination pair approach is employed to derive putative protein domain–domain interactions (DDI) from the protein–protein interactions (PPI) database DIP. The results of putative DDI are computed for seven species. To determine the prediction performance, putative DDI results are compared with that of the database InterDom, where an average matching ratio of about 76% can be achieved.

    Several real PPI pathways are reconstructed based on the predicted DDI results. It is found that the pathways could be reconstructed with reasonable accuracy. Furthermore, a novel quantity, so called AP-order index, is introduced to predict the regulatory order for six PPI pathways. It is found that the AP-order index is a very reliable parameter to determine the regulatory order of PPI.
    Relation: Computational Biology and Chemistry,32(2),81-87.
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

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