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    题名: Applications of domain-domain interactions in pathway study
    作者: 吳家樂;Ng, Ka-Lok;劉湘川;Liu, Hsiang-Chuan
    贡献者: 生物與醫學資訊學系
    关键词: Protein–protein interaction;Domain–domain interaction;Chemotaxis pathway;Blood coagulation pathway;MAPK pathway;Entropy
    日期: 2008
    上传时间: 2012-11-23 17:14:53 (UTC+8)
    摘要: The domain combination pair approach is employed to derive putative protein domain–domain interactions (DDI) from the protein–protein interactions (PPI) database DIP. The results of putative DDI are computed for seven species. To determine the prediction performance, putative DDI results are compared with that of the database InterDom, where an average matching ratio of about 76% can be achieved.

    Several real PPI pathways are reconstructed based on the predicted DDI results. It is found that the pathways could be reconstructed with reasonable accuracy. Furthermore, a novel quantity, so called AP-order index, is introduced to predict the regulatory order for six PPI pathways. It is found that the AP-order index is a very reliable parameter to determine the regulatory order of PPI.
    關聯: Computational Biology and Chemistry,32(2),81-87.
    显示于类别:[生物資訊與醫學工程學系 ] 期刊論文


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