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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16627


    Title: The roles of EZH2 in cell lineage commitment
    Authors: 鄒瑞煌;Chou, Ruey-Hwang;余永倫;Yu, Yung-luen;洪明奇;Hung, Mien-Chie
    Contributors: 生物科技學系
    Keywords: EZH2;stem cells;cell lineage;differentiation
    Date: 2011-05
    Issue Date: 2012-11-23 17:15:15 (UTC+8)
    Abstract: Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2 (PRC2), epigenetically regulates chromatin structure and gene expressions through tri-methylation at histone H3K27 and recruitment of DNA methyltransferases for gene silencing. Despite extensive studies of the role of EZH2 in cancer progression and malignancy, increasing evidence also suggest that EZH2 plays a critical role in stem cells renewal, maintenance, and differentiation into specific cell lineages. Here, we review the updated information regarding how EZH2 contributes to stem cell maintenance, cell lineage determination, including myogenesis, adipogenesis, osteogenesis, neurogenesis, hematopoiesis, lymphopoiesis, epidermal differentiation and hepatogenesis, and how EZH2 is regulated by phosphorylation and microRNAs in these processes.
    Relation: American Journal of Translational Research
    Appears in Collections:[生物科技學系] 期刊論文

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