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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16656


    Title: Lose weight with traditional chinese medicine? potential suppression of fat mass and obesity-associated protein.
    Authors: 張培均;Chang, Pei-Chun;王經篤;Wang, Jing-Doo;李明明;Lee, Min-Min
    Contributors: 生物與醫學資訊學系
    Keywords: "Obesity;Traditional Chinese Medicine (TCM);FTO;Docking;Molecular Dynamics."
    Date: 2012
    Issue Date: 2012-11-23 17:15:34 (UTC+8)
    Abstract: "Overweight and obesity are common health problems in modern society, particularly in
    developed countries. Excessive body mass has been linked to numerous diseases, such as
    cardiovascular diseases, diabetes, and cancer. Fat mass and obesity-associated protein (FTO)
    activity have direct impact on food intake and results in obesity. Inhibition of FTO activity
    may cause weight loss and reduce obese-linked health risks. We investigated the potential weight loss effects of traditional Chinese medicine (TCM), particularly by inhibiting
    FTO functions. Molecular docking was performed to screen TCM compounds from TCM
    Database@Taiwan (http://tcm.cmu.edu.tw). Three candidates were identified that contained
    either a tetrahydropyridine group or potent electronegative phenol group in the structure
    scaffold. Molecular dynamics simulation analysis of the docking poses of each complex
    indicated stabilizing trends in the protein-ligand complex movements. In addition, the number of hydrogen bonds increased throughout the 20ns simulation. These results suggest that
    these TCM candidates could be potential FTO inhibitors through competitive inhibition."
    Relation: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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