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    Title: Robustness of Protein Complex Networks
    Authors: 吳家樂;Ng, Ka-Lok
    Contributors: 生物與醫學資訊學系
    Keywords: "protein complex;protein-protein interaction;network diameter;network robustness;"
    Date: 2012
    Issue Date: 2012-11-23 17:15:36 (UTC+8)
    Abstract: "The stability and fragility of four species’ (rat, yeast,
    mouse, human) protein complex networks (PCNs) are studied
    by investigating their robustness, i.e. whether their global
    topological properties, especially average diameter, retain a
    similar system behavior with respect to four different types of
    perturbations or not. Four types of perturbations consist of ˍ
    (i) network edges are randomly removed, (ii) network nodes
    are randomly deleted (failure), (iii) the most connected nodes
    are successively removed (attack), and (iv) interaction edges
    are randomly rewired. In the ex pe ri me nt of t hi s
    paper, at most 40% of network nodes or edges are deleted
    or rewired. It is demonstrated that, except mouse organism
    and attack perturbation, the average diameters for perturbed
    networks differ from the unperturbed cases in less than 13%,
    which is small in comparison with WWW and the Internet
    results. That is, the protein complex networks of rat, yeast and
    human species are quite robust with respect to failure, rewiring
    and edge deletion perturbations, but not robust against the
    attack one"
    Relation: The 2nd International Conference on Computer Science and Service System
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

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