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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16673


    Title: A cross-species study of the protein-protein interaction networks via the random graph approach
    Authors: 吳家樂;Ng, Ka-Lok
    Contributors: 生物與醫學資訊學系
    Date: 2004-05
    Issue Date: 2012-11-23 17:15:44 (UTC+8)
    Abstract: We employed the random graph theory approach
    to analyze the protein-protein interacting database
    DIP (Oct. 7 and Nov. 25, 2003), for six different
    species (S. cerevisiae, H. pylori, E. coli, H. sapiens, M.
    musculus and D. melanogaster). Two global
    topological parameters (node connectivity, average
    diameter) were used to characterize these
    protein-protein interaction networks (PINs). The
    logarithm of the connectivity distribution vs. the
    logarithm of connectivity plot indicates that it follows
    a power law behavior quite well for the six species.
    We also demonstrated that the interaction networks are
    quite robust when subject to random perturbation.
    Node degree correlation study supports the earlier
    results that nodes of low connectivity are correlated,
    whereas nodes of high connectivity are not directly
    linked. These results provided some evidence
    suggesting such correlation relations might be a
    general feature of the PINs across different species.
    Relation: Proceedings of the IEEE
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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