We investigate the possibility that microRNA could act as an oncogene or tumor suppressor gene. Experimentally verified microRNA targeted genes information are integrated with microRNA and mRNA expression data to study this hypothesis, in which the Pearson correlation coefficient is used to quantify these relations. Cancer related microRNA and genes information are retrieved by literature search. Two microRNA targets prediction tools, miRanda and RNAHybrid, are used to obtained the binding minimum free energy and 3’UTR binding position for the target. A web based interface is set up for data display, which can be accessed at http://ppi.bioinfo.asia.edu.tw/mirna_target.
Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering