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    Title: Protein Complexes Subunits Interaction Topology and Sequence Identity
    Authors: 吳家樂;Ng, Ka-Lok
    Contributors: 生物與醫學資訊學系
    Keywords: protein complex;protein-protein interaction;sequence similarity;clique;topological parameters
    Date: 2011-03
    Issue Date: 2012-11-23 17:16:37 (UTC+8)
    Abstract: "Many protein complexes prediction approaches are
    based on the assumptions that (i) protein complexes have dense
    protein-protein interactions (PPI) among their subunits, and (ii)
    high functional similarity for the subunits. We suggest to
    investigate those assumptions by studying the subunits’
    interaction topology and sequences identity. Such
    consideration can possibly provide better insights for our
    understanding of protein complexes architecture. Two
    topological parameters, density of protein-protein interaction
    (PPI) and connectedness, are defined to test whether protein
    complex are found in PPI dense region or not. The present
    data indicated that interaction dense regions represent protein
    complexes up to 20% cases. A rather large proportion of
    protein complexes have a lower density of PPI, and
    connectedness. It is conjectured that prediction approaches
    based on the assumption that complexes are composed of
    highly PPI dense regions, connectedness can predict a rather
    limited numbers of the complexes. On the other hand, our
    result indicates that protein complexes do composing of
    subunits with higher sequence identity or similarity. "
    Relation: IEEE International conference on computer research and development 2011 (ICCRD 2011)
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

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