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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16819

    Title: An Extract of Agaricus blazei Murill Administered Orally Promotes Immune Responses in Murine Leukemia BALB/c Mice In Vivo.
    Authors: 范宗宸;Fan, Ming-Jen;鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: Agaricus blazei Murill extract, immune responses, WEHI-3 cells, NK cells, phagocytosis, leukemia BALB/c mice
    Date: 2012-03
    Issue Date: 2012-11-23 17:17:22 (UTC+8)
    Abstract: "Purpose. The edible mushroom (fungus) Agaricus blazei Murill (ABM) is a health food in many countries. Importantly,
    it has been shown to have antitumor and immune effects. There is no available information on ABM-affected immune
    responses in leukemia mice in vivo. Experimental Design. In this study, the authors investigated the immunopotentiating
    activities of boiled water–soluble extracts from desiccated ABM in WEHI-3 leukemia mice. The major characteristic
    of WEHI-3 leukemia mice are enlarged spleens and livers after intraperitoneal injection with murine leukemia WEHI-3
    cells. Isolated T cells from spleens of ABM-treated mice resulted in increased T-cell proliferation compared with the
    untreated control with concanavalin A stimulation. Results. ABM decreased the spleen and liver weights when compared
    with WEHI-3 leukemia mice and this effect was a dose-dependent response. ABM promoted natural killer cell activity and
    phagocytosis by macrophage/monocytes in leukemia mice in a dose-dependent manner. ABM also enhanced cytokines such
    as interleukin (IL)-1b, IL-6, and interferon-g levels but reduced the level of IL-4 in WEHI-3 leukemia mice. Moreover, ABM
    increased the levels of CD3 and CD19 but decreased the levels of Mac-3 and CD11b in leukemia mice. Conclusions. The
    ABM extract is likely to stimulate immunocytes and regulate immune response in leukemia mice in vivo."
    Appears in Collections:[生物科技學系] 期刊論文

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