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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16821


    Title: Butylated hydroxyanisole affects immunomodulation and promotes macrophage phagocytosis in normal BALB/c mice
    Authors: ;鍾景光;Chung, Jing-Gung
    Contributors: 生物科技學系
    Keywords: "butylated hydroxyanisole;macrophages;natural killer cells;phagocytosis"
    Date: 2012-03
    Issue Date: 2012-11-23 17:17:23 (UTC+8)
    Abstract: "Butylated hydroxyanisole (BHA), a synthetic
    antioxidant, has been used in fat and fatty foods to prevent
    oxidative deterioration. However, the functions of BHA on
    immune responses in normal mice remain elusive. The aim of
    the present study was to investigate the effects of oral treatment of BHA on immune responses in normal mice in vivo.
    BALB/c mice received various treatments. Blood samples were
    collected and analyzed. Flow cytometry was used to determine
    the levels of the cell markers. Results showed that BHA did not
    significantly affect the weight of the animal body and spleen in
    normal mice. BHA promoted macrophage phagocytosis from
    peripheral blood mononuclear cells, but did not alter this process
    in the peritoneal cavity. Furthermore, BHA did not influence
    natural-killer cell cytotoxicity in normal mice. Notably, BHA
    promoted the levels of CD3 (T cells) and decreased the level
    of CD19 (B cells), but did not significantly affect the levels of
    CD11b (monocytes) and macrophages (Mac-3) in normal mice.
    Based on these observations it can be concluded that BHA
    promotes immune responses by increasing T cells and activating phagocytosis by macrophages in normal mice. However,
    the molecular mechanisms require further investigation."
    Relation: Molecular Medicine Reports
    Appears in Collections:[生物科技學系] 期刊論文

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