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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17261

    Title: Anti-glycative effects of protocatechuic acid in kidney of diabetic mice
    Authors: 林佳育;LIN, CY;黃晉修;Huang, Chin-Shiu;殷梅津;YIN, MEI-CHIN
    Contributors: 保健營養生技學系
    Keywords: protocatechuic acid;diabetes;glycation;aldose reducatse;protein kinase C
    Date: 2011-04
    Issue Date: 2012-11-26 10:30:42 (UTC+8)
    Abstract: "Protocatechuic acid (PCA) at 2 or 4% was supplied to diabetic mice for 12 wks. PCA
    3 treatments increased its deposit in organs, and significantly reduced plasma HbA1c level,
    4 urinary glycative albumin level, and renal production of carboxymethyllysine (CML),
    5 pentosidine, sorbitol and fructose (P<0.05). However, PCA treatments only at 4%
    6 significantly decreased brain content of CML, pentosidine, fructose and sorbitol (P<0.05).
    7 PCA treatments at 2 and 4% significantly lowered renal activity and mRNA expression of
    8 aldose reductase and sorbitol dehydrogenase (P<0.05); and only at 4% significantly enhanced
    9 renal glyoxalase I mRNA expression (P<0.05). PCA treatments also dose-dependently
    10 decreased renal level of type IV collagen, fibronectin and transforming growth factor-beta1
    11 (P<0.05), as well as dose-dependently diminished renal protein kinase C (PKC) activity
    12 (P<0.05); however, only at 4% suppressed renal mRNA expression of PKC-alpha and
    13 PKC-beta (P<0.05). PCA treatments at 4% significantly restored renal mRNA expression of
    14 peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma, as well as
    15 suppressed expression of advanced glycation endproduct receptor (P<0.05). These findings
    16 suggest that the supplement of protocatechuic acid might be helpful for the prevention or
    17 alleviation of glycation associated diabetic complications."
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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