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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17299

    Title: Anti-oxidative and Anti-inflammatory Protection from Carnosine in Striatum of MPTP-treated Mice
    Authors: 殷梅津;YIN, MEI-CHIN
    Contributors: 保健營養生技學系
    Keywords: carnosine;Parkinson’sdisease;oxidative stress;iNOS activity;mRNA;expression
    Date: 2010-12
    Issue Date: 2012-11-26 10:31:12 (UTC+8)
    Abstract: "Mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used to
    3 examine the neuroprotective effects of carnosine. Carnosine at 0.5, 1 and 2 g/L was
    4 directly added to the drinking water for 4 wk. MPTP treatment significantly depleted
    5 striatal glutathione content, reduced the activity of glutathione peroxidase (GPX),
    6 superoxide dismutase (SOD) and catalase, increased malondialdehyde and reactive oxygen
    7 species levels, and elevated interleukin-6, nitrite and tumor necrosis factor-production as
    8 well as enhanced inducible nitric oxide synthase (iNOS) activity in striatum (P<0.05).
    9 The pre-intake of carnosine significantly attenuated MPTP-induced glutathione loss,
    10 retained the activity of GPX and SOD, diminished oxidative stress, and lowered
    11 inflammatory cytokines and nitrite levels as well as suppressed iNOS activity (P<0.05).
    12 MPTP treatment significantly suppressed GPX mRNA expression and enhanced iNOS
    13 mRNA expression (P<0.05). Carnosine pre-intake significantly elevated GPX mRNA
    14 expression and declined iNOS mRNA expression (P<0.05). Pre-intake of carnosine also
    15 significantly improved MPTP-induced dopamine depletion and maintained
    16 3,4-dihydroxyphenylacetic acid and homovanillic acid levels (P<0.05). These results
    17 suggest that carnosine could provide anti-oxidative and anti-inflammatory protection for the
    18 striatumagainstthedevelopmentofParkinson’sdisease."
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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