ASIA unversity:Item 310904400/17339
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17339


    Title: Synergistic effects of the combination of beta-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells
    Authors: Chin-Shiu Huang;Shih-Chieh Lyu;Miao-Lin Hu
    Contributors: 保健營養生技學系
    Keywords: β-Ionone;Sorafenib;Metastasis;Focal adhesion kinase;Tissue inhibitor matrix metalloproteinase
    Date: 2012-08
    Issue Date: 2012-11-26 10:31:43 (UTC+8)
    Abstract: The combination of anti-cancer drugs with nutritional factors is a potential strategy for improving the efficacy of chemotherapy, particularly for hepatocellular carcinoma because its conventional therapies are mostly ineffective. Using a highly invasive hepatoma SK-Hep-1 cell line, we investigated the possible synergistic anti-metastatic efficacy of a combination of sorafenib (SF), a multi-kinase inhibitor, and β-ionone (BI), a precursor of carotenoids. We found that SF (1 μM) in combination with BI (1 μM) synergistically inhibited cell invasion and additively inhibited cell migration, especially at 48 h of incubation. Mechanistically, the combination of SF and BI was found to decrease the protein expression of focal adhesion kinase (FAK) and Rho, and to enhance the protein expression of tissue inhibitor matrix metalloproteinase (TIMP)-1 and TIMP-2. In addition, the combination of SF and BI inhibited the activity of matrix metalloproteinase (MMP)-2 and MMP-9 and decreased the phosphorylation of FAK and of Rac1 proteins. Importantly, SF enhanced the suppressing effect of BI (1–50 μM) on the viability of SK-Hep-1 cells, but not on murine hepatic BNL CL.2 cells, indicating the selective cytotoxicity of this combination on tumor cells. The combination of SF and BI could be a potential therapeutic strategy against human hepatoma cells.
    Relation: INVESTIGATIONAL NEW DRUGS, 30(4):1449-1459.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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