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    Title: Antihyperglycemic and antioxidative potential of Psidium guajava fruit in streptozotocin-Induced diabetic rats
    Authors: 黃晉修;Huang, Chin-Shiu;殷梅津;YIN, MEI-CHIN
    Contributors: 保健營養生技學系
    Date: 2011-09
    Issue Date: 2012-11-26 10:31:43 (UTC+8)
    Abstract: Psidium guajava Linn. (family Myrtaceae; PG) is a tropical fruit with a blood-glucose-lowering effect in diabetic rats, but its mechanism of action is still unknown. We investigated the antihyperglycemic efficacy and mechanisms of action of PG in streptozotocin (STZ)-induced diabetic rats. After 4 weeks of PG supplementation (125 and 250 mg/kg), PG significantly restored the loss of body weight caused by STZ and reduced blood glucose levels in a dose-dependent manner compared with that in diabetic control rats. Mechanistically, PG protected pancreatic tissues, including islet β-cells, against lipid peroxidation and DNA strand breaks induced by STZ, and thus reduced the loss of insulin-positive β-cells and insulin secretion. Moreover, PG also markedly inhibited pancreatic nuclear factor-kappa B protein expression induced by STZ and restored the activities of antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase. We conclude that PG has a significant antihyperglycemic effect, and that this effect is associated with its antioxidative activity.
    Relation: FOOD AND CHEMICAL TOXICOLOGY; 49(9):2189-95.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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