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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17357

    Title: Antiangiogenic potential of three triterpenic acids in human liver cancer cells
    Authors: 蒙美津;Mong, Mei-Chin;殷梅津;YIN, MEI-CHIN
    Contributors: 保健營養生技學系
    Keywords: "Angiogenesis;triterpenic acid;liver cancer cell;hypoxia-inducible factor;vascular endothelial growth factor"
    Date: 2011-01
    Issue Date: 2012-11-26 10:31:56 (UTC+8)
    Abstract: "Three triterpenic acids, oleanolic acid, ursolic acid and maslinic acid, at 2 or 4 μmol/L were used to
    study their antiangiogenic potential in human liver cancer Hep3B, Huh7 and HA22T cell lines. The
    effects of these compounds upon the level and/or expression of hypoxia-inducible factor (HIF)-1R,
    basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), interleukin (IL)-8,
    urokinase plasminogen activator (uPA), reactive oxygen species (ROS), nitric oxide (NO) and cell
    invasion and migration were examined. Results showed that these triterpenic acids at 4 μmol/L
    significantly suppressed HIF-1R expression in three cell lines (P < 0.05); and these compounds at
    test doses failed to affect bFGF expression (P > 0.05). Three triterpenic acids dose-dependently
    decreased production and expression of VEGF and IL-8, retained glutathione level, lowered ROS
    and NO levels, and declined cell invasion and migration in test cell lines (P < 0.05). These
    compounds also dose-dependently reduced uPA production and expression in Hep3B and Huh7 cell
    lines (P < 0.05); but these agents only at 4 μmol/L significantly suppressed uPA production and
    expression in HA22T cells (P < 0.05). These findings suggest that these triterpenic acids are potent
    antiangiogenic agents to retard invasion and migration in liver cancer cells."
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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