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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17361

    Title: Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet. European Journal of Pharmacology
    Authors: 蒙美津;Mong, Mei-Chin;趙哲毅;Chao, Che-Yi;殷梅津;YIN, MEI-CHIN*
    Contributors: 保健營養生技學系
    Keywords: Carnosine;Histidine;Steatosis;SREBPs;Insulin
    Date: 2011-01
    Issue Date: 2012-11-26 10:31:59 (UTC+8)
    Abstract: The effects of histidine, alanine and carnosine on activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in liver and adipose tissue from high fat diet treated mice were examined. Histidine, alanine or carnosine, each agent at 1 g/l was added into drinking water for 8-wk supplement. Histidine or carnosine supplement increased hepatic levels of alanine, histidine and carnosine. High fat diet evoked lipogenesis via raising the activity and mRNA expression of glucose-6-phosphate dehydrogenase, malic enzyme, fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, SREBP-1a, -1c and -2 in liver and adipose tissue (P < 0.05), which consequently increased mice body weight, epididymal fat, and hepatic triglyceride and cholesterol contents (P < 0.05). The intake of histidine or carnosine significantly diminished the activity and mRNA expression of malic enzyme, FAS, HMG-CoA reductase, SREBP-1c and SREBP-2, which led to lower body weight, epididymal fat, and hepatic triglyceride and cholesterol levels (P < 0.05). Mice consumed high fat diet exhibited hyper-insulinemia, hyper-leptinemia, hypo-adiponectinemia and hypo-ghrelinemia. Histidine or carnosine treatments significantly improved insulin sensitivity and attenuated hyper-insulinemia (P < 0.05). These results support that histidine and carnosine are effective agents for mitigating high fat diet induced hepatic steatosis.
    Relation: EUROPEAN JOURNAL OF PHARMACOLOGY; 653(1–3):Pages 82–88.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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