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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17375

    Title: Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice
    Authors: 趙哲毅;Chao, Che-Yi;殷梅津;YIN, MEI-CHIN;Ching-jang Huang
    Contributors: 保健營養生技學系
    Keywords: Wild bitter gourd;PPARα;PPARγ;Adiponectin
    Date: 2011-04
    Issue Date: 2012-11-26 10:32:10 (UTC+8)
    Abstract: Ethnopharmacological relevance
    Wild bitter gourd (Momordica charantia Linn. var. abbreviata ser.) was commonly used as a medicinal herb in Asia, Africa, and South America because of its anti-diabetic, antibacterial, anti-viral, and chemopreventive functions.

    Materials and methods
    C57BL/6J mice were orally administered with 250, 500 or 1000 mg/kg BW of WBGE in 0.2 mL/mouse of olive oil daily for 2 weeks.

    Compared to control (vehicle treated) mice, mice receiving WBGE showed significantly higher PPARα, ACO (acyl-CoA oxidase) and L-FABP (liver-fatty acid binding protein) mRNA expression, ACO activity and protein in the liver (P < 0.05), as clofibrate-treated mice. WBGE treatment also resulted in significantly higher PPARγ and LPL (lipoprotein lipase) mRNA (P < 0.05) in the epididymal adipose tissue. Liver triglyceride and non-esterified fatty acid concentration in WBGE treated mice were significantly lower than those of control mice (P < 0.05). Plasma adiponectin level was significantly higher in mice receiving WBGE than in control mice (P < 0.05), as the rosiglitazone treated mice.

    Results of this study demonstrated that WBGE also activates PPARα and PPARγ signaling pathway in vivo.
    Relation: JOURNAL OF ETHNOPHARMACOLOGY, 135(1):156-161.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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