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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17383


    Title: Monoclonal Antibodies Targeting the Synthetic Peptide Corresponding to the Polybasic Cleavage Site on H5N1 Influenza Hemagglutinin
    Authors: 蔡建鈞;Tsai, Henry Jan-Jen
    Contributors: 保健營養生技學系
    Keywords: Monoclonal antibody, Polybasic cleavage site;Hemagglutinin;H5N1 influenza
    Date: 2012-04
    Issue Date: 2012-11-26 10:32:17 (UTC+8)
    Abstract: "Background

    Avian influenza H5N1 virus is highly pathogenic partially because its H5 hemagglutinin contains a polybasic cleavage site that can be processed by proteases in multiple organs.

    Methods

    Monoclonal antibodies (mAb) specific to the synthetic peptide of hemagglutinin polybasic cleavage site of H5N1 virus were raised and tested for their neutralizing potential.

    Results

    Purified mAb showed suppression of H5N1 pseudovirus infection on Madin-Darby Canine Kidney (MDCK) cells but the efficacy was less than 50%. Since those mAb are specific to the intact uncut polybasic cleavage site of hemagglutinin, their efficacy depends on the extent of hemagglutinin cleavage on the viral surface.

    Conclusions

    Proteolytic analysis suggests the low efficacy associated with those mAb may be due to proteolytic cleavage already present on the majority of hemagglutinin prior to the infection of virus."
    Relation: JOURNAL OF BIOMEDICAL SCIENCE; 9:37. doi: 10.1186/1423-0127-19-37.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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