Antioxidant, Anti-inflammatory, and Antiproliferative Activities of Taxillus sutchuenensis

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/17405

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Title:	Antioxidant, Anti-inflammatory, and Antiproliferative Activities of Taxillus sutchuenensis
Authors:	鄧正賢;Deng, Jeng-Shyan
Contributors:	保健營養生技學系
Keywords:	Chinese Medicine;Taxillus sutchuenensis;Antioxidant Activity;Anti-inflammatory Activity;Antiproliferation
Date:	2012-03
Issue Date:	2012-11-26 10:32:34 (UTC+8)
Abstract:	Inflammation is related to several chronic diseases, including cancer and atherosclerosis. Taxillus sutchuenensis (Lecomte) Danser is a special folk medicinal plant in Taiwan. The aim of this study was to evaluate the antioxidant, anti-inflammatory, and antiproliferative activities of the aqueouse-thanol extract from T. sutchuenensis (AETS) and its fractions. TEAC, DPPH radicals, total phenolic compounds, total flavonoid content, inhibition of NO production in LPS-induced RAW264.7 cells, and inhibition of cancer cell proliferation were tested. Among all fractions, the ethyl-acetate (EA) fraction showed the highest TEAC and DPPH radical scavenging activities. The EA fraction also had the highest polyphenol and flavonoid content. The EA fractions also decreased LPS-induced NO production and the expression of iNOS and COX-2 in RAW264.7 cells. The antiproliferative activities of the aqueous/ethanol extract and fractions were studied in vitro using A549 cells, and the results were consistent with their antioxidant capacities. EA fractions had the highest antiproliferative activity with an IC50 of 454.38 ± 1.48 μg/ml. Quercetin also had antioxidant, anti-inflammatory, and antiproliferative activities. Quercetin might be an important bioactive compound in T. sutchuenensis. The experimental data indicated that T. sutchuenensis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds.[ABSTRACT FROM AUTHOR] Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.Copyright applies to all Abstracts.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE, 40(2):335-348.
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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