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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17430


    Title: Effect of taurine on toxicity of aluminum in rats.
    Authors: Yen-Hung Yeh;Ya-Ting Lee;Hung-Sheng Hsieh;Deng-Fwu Hwang
    Contributors: 保健營養生技學系
    Keywords: Aluminum;Taurine;Toxicity;Hepatotoxicity;Nephrotoxicity;Rats
    Date: 2009
    Issue Date: 2012-11-26 10:32:55 (UTC+8)
    Abstract: Background & aims
    A study was undertaken to investigate the effect of taurine on the toxicity of aluminum in male Wistar rats.

    Methods
    The rats were divided into six groups and fed different diets with or without 5% taurine and 150–300 ppm aluminum added for 2 months.

    Results
    It was found that the body weight of rats, the ratios of liver and kidney weight to body weight, and the level of glutathione in the liver were decreased with increasing the dose of aluminum. The levels of aluminum in the liver and kidney, the levels of TBARS in the plasma and liver, the activities of AST and ALT in the plasma and the levels of BUN and creatinine in the plasma of rats were increased with the increasing dose of aluminum. Hence, symptoms of aluminum toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity.

    Conclusions
    However, these toxic effects of aluminum were significantly reduced when the rats fed diet with taurine added. Furthermore, the level of aluminum in the feces of rats treated with taurine and aluminum was higher than that of rats treated with aluminum alone. It indicated that taurine might play a role in reducing the toxic effect of aluminum in rats.
    Relation: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, 4(4):187-192.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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