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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17444


    Title: Dietary Cholestin (Red Yeast Extract) Reduces Toxicity of Oxidized Cholesterol in Rats
    Authors: YEN-HUNG YEH;YA-TING LEE;HUNG-SHENG HSIEH;DENG-FWU HWANG
    Contributors: 保健營養生技學系
    Keywords: cholestin, oxidized cholesterol, toxic effect, rats, liver function
    Date: 2010-06
    Issue Date: 2012-11-26 10:33:03 (UTC+8)
    Abstract: "This study focused on the effects of dietary cholestin (red yeast extract) on the toxicity of oxidized cholesterol in rats. The rats
    were divided into eight groups and fed with or without supplement of 1% cholestin and 3% oxidized cholesterol in their diets for 8
    weeks. It was found that cholestin could improve the body weight decrease and the glutathione (GSH) level in the liver, and increase
    of liver and kidney weight to body weight ratio, and thiobarbituric acid-reactive substances (TBARS) level in the liver of rats caused
    by oxidized cholesterol (P < 0.05). It also reduced the plasma content of alanine transaminase (ALT), aspartate transaminase (AST)
    and alkaline phosphatase (ALP), indicating that cholestin could prevent the hepatotoxicity induced by oxidized cholesterol (P < 0.05).
    In addition, cholestin possessed recovering effect and a short-term preventing effect on the toxicity of oxidized cholesterol in rats.
    Taking all these data together, cholestin may play an important role in diminishing the toxic effects of oxidized cholesterol in rats."
    Relation: JOURNAL OF FOOD AND DRUG ANALYSIS, 18(3):211-220.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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