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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17455

    Title: Effect of Cholestin on toxicity of vitamin A in rats
    Authors: Yen-Hung Yeh;Ya-Ting Lee;You-Liang Hsieh
    Contributors: 保健營養生技學系
    Keywords: Vitamin A;Cholestin;Toxicity;Hepatotoxicity;Nephrotoxicity
    Date: 2012-05
    Issue Date: 2012-11-26 10:33:09 (UTC+8)
    Abstract: A study was undertaken to investigate the effect of cholestin on the toxicity of vitamin A in male wistar rats. The rats were divided into six groups and fed different diets with or without supplement of 1% cholestin and 25,000–50,000 (IU) vitamin A for 2 months. Hence, the symptoms of vitamin A toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity. However, these toxic effects of vitamin A were significantly reduced when the rats fed a diet supplemented with cholestin. Furthermore, the level of vitamin A in the serum of rats treated with cholestin and vitamin A was higher than that of the rats treated with vitamin A alone. It indicated that cholestin might play a role in reducing the toxic effect of vitamin A in rats.
    Relation: FOOD CHEMISTRY, 132(1):311-318.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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