ASIA unversity:Item 310904400/17846
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    题名: Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults
    作者: Fen-Yu Tseng;Wen-Yuan Lin;Cheng-Chieh Lin;Long-Teng Lee;Tsai-Chung Li;Pei-Kun Sung;Kuo-Chin Huang
    贡献者: 健康產業管理學系
    关键词: all-cause mortality;cardiovascular disease mortality;subclinical hypothyroidism
    日期: 2012
    上传时间: 2012-11-26 12:04:24 (UTC+8)
    摘要: This study sought to evaluate the relationship between subclinical hypothyroidism (SCH) and all-cause and cardiovascular disease (CVD) mortality.

    Background
    SCH may increase the risks of hypercholesterolemia and atherosclerosis. The associations between SCH and all-cause or CVD mortality are uncertain, on the basis of the results of previous studies.

    Methods
    A baseline cohort of 115,746 participants without a history of thyroid disease, ≥20 years of age, was recruited in Taiwan. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0 to 19.96 mIU/l with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47 to 4.9 mIU/l. Cox proportional hazards regression analysis was used to estimate the relative risks (RRs) of death from all-cause and CVD for adults with SCH during a 10-year follow-up period.

    Results
    There were 3,669 deaths during the follow-up period; 680 deaths were due to CVD. Compared with subjects with euthyroidism, after adjustment for age, sex, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol consumption, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval) of deaths from all-cause and CVD among subjects with SCH were 1.30 (1.02 to 1.66), and 1.68 (1.02 to 2.76), respectively.

    Conclusions
    Adult Taiwanese with SCH had an increased risk for all-cause mortality and CVD death.
    關聯: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(8):730-737.
    显示于类别:[健康產業管理學系] 期刊論文

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