ASIA unversity:Item 310904400/18008
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90570/105786 (86%)
造访人次 : 16362440      在线人数 : 335
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/18008


    题名: Granulocyte Colony-Stimulating Factor Activating HIF-1a Acts Synergistically with Erythropoietin to PromoteTissue Plasticity
    作者: Shih-Ping Liu;Shin-Da Lee;Hsu-Tung Lee;Demeral David Liu;Hsiao-Jung Wang;Ren-Shyan Liu;Shinn-Zong Lin;Woei-Cherng Shyu
    贡献者: 健康產業管理學系
    日期: 2010-04
    上传时间: 2012-11-26 12:06:34 (UTC+8)
    摘要: "Stroke and peripheral limb ischemia are serious clinical problems with poor prognosis and limited treatment. The
    cytokines erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) have been used to induce endogenous
    cell repair and angiogenesis. Here, we demonstrated that the combination therapy of EPO and G-CSF exerted synergistic
    effects on cell survival and functional recovery from cerebral and peripheral limbs ischemia. We observed that even under
    normoxic conditions, G-CSF activates hypoxia-inducible factor-1a (HIF-1a), which then binds to the EPO promoter and
    enhances EPO expression. Serum EPO level was significantly increased by G-CSF injection, with the exception of Tg-HIF-
    1a
    +f/+f
    mice. The neuroplastic mechanisms exerted by EPO combined with G-CSF included enhanced expression of the
    antiapoptotic protein of Bcl-2, augmented neurotrophic factors synthesis, and promoted neovascularization. Further, the
    combination therapy significantly increased homing and differentiation of bone marrow stem cells (BMSCs) and intrinsic
    neural progenitor cells (INPCs) into the ischemic area. In summary, EPO in combination with G-CSF synergistically
    enhanced angiogenesis and tissue plasticity in ischemic animal models, leading to greater functional recovery than either
    agent alone."
    關聯: PUBLIC LIBRARY of SCIENCE,5(4):e10093.
    显示于类别:[健康產業管理學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML211检视/开启
    Granulocyte Colony-Stimulating Factor.pdf1482KbAdobe PDF222检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈